abstract：:Secreted frizzled-related protein 5 (Sfrp5), an anti-inflammatory adipocytokine secreted by adipocytes, plays an important role in energy metabolism. Studies have shown that Sfrp5 plays a salutary role in the regulation of lipid metabolism, but its specific mechanism needs further study. In this study, we showed a low...

journal_title：Biochemical and biophysical research communications

authors： Zhao A,Jiang F,Yang G,Liu H,Li L

更新日期：2019-04-30 00:00:00

abstract：:Moderate alcohol consumption has been shown to reduce atherosclerosis-associated diseases. As shown in our earlier works, ethanol has a dose-dependent protective effects against endothelial cellular senescence by activating aldehyde dehydrogenase 2 (ALDH2) in vitro. However, whether ethanol administration possesses an...

journal_title：Biochemical and biophysical research communications

authors： Xue L,Zhu W,Yang F,Dai S,Han Z,Xu F,Guo P,Chen Y

更新日期：2019-04-30 00:00:00

abstract：:CYP2A5 is a major enzyme responsible for nicotine and cotinine metabolism in mice. Nicotine and cotinine enhance alcoholic fatty liver in wild type (WT) mice but not in CYP2A5 knockout (KO) mice, and reactive oxygen species (ROS) generated during the CYP2A5-mediated metabolism contributes to the enhancing effect. In c...

journal_title：Biochemical and biophysical research communications

authors： Chen X,Wang K,Cederbaum AI,Lu Y

更新日期：2019-04-23 00:00:00

abstract：:Neutrophil extracellular traps (NETs) play a critical role in host antimicrobial response whereas they are also implicated in the pathogenesis of inflammatory and autoimmunediseases. Generation of reactiveoxygen species (ROS) is key to NETs formation. A variety of stimulatory ligands have been found to enhance ROS pro...

journal_title：Biochemical and biophysical research communications

authors： Zhu Y,Yang Y,Li F,Fan S,Chen X,Lu Y,Wei Y,Chen Q,Xia L,Tang J,Huang Q,Zhu Q,Zheng J,Liu X

更新日期：2019-04-16 00:00:00

abstract：:Several groups have demonstrated that induction of heme-oxygenase-1 (HO-1) could protect the myocardium against ischemic events; however, heme accumulation could lead to toxicity. The aim of the present study was to investigate the role of autophagy in heme toxicity. H9c2 cardiomyoblast cells were treated with differe...

journal_title：Biochemical and biophysical research communications

authors： Gyongyosi A,Szoke K,Fenyvesi F,Fejes Z,Debreceni IB,Nagy B Jr,Tosaki A,Lekli I

更新日期：2019-04-16 00:00:00

abstract：BACKGROUND/AIMS:The expression of transcription factor Zbtb1 is essential for the maintenance and development of various blood cells in the hematopoietic system. In the current study, we found that the total number of thymocytes in PLZF deficient mice was reduced compared with thymocytes in wild-type mice, and the numb...

journal_title：Biochemical and biophysical research communications

authors： Du JL,Cao X,Liu HY,Zeng Y,Yang XC,Wan XM,Chang FF,Zhao TY,Jia XY,Wang HZ,Liu J,Cai KZ,Ma ZR

更新日期：2019-04-16 00:00:00

abstract：:The relationship between colorectal cancer (CRC) and cholesterol has been confirmed for many years, but the mechanism was not very clear. miR-33a was important in cholesterol metabolism and was abnormally expressed in many tumors, thus our study hypothesized that cholesterol effect on CRC by regulating miR-33a and its...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Liu C,Hu L

更新日期：2019-04-09 00:00:00

abstract：:The prevalence of nonalcoholic fatty liver disease (NAFLD) is high and increasing throughout the world. The intense sterile inflammation stemming from steatosis plays a significant role in the development of NAFLD, but the mechanism is unclear. We found that the NLRC4 inflammasome was activated in an in vitro cell mod...

journal_title：Biochemical and biophysical research communications

authors： Chen Y,Ma K

更新日期：2019-04-09 00:00:00

abstract：:The purpose of this investigation was to find out whether C-terminally end-cleaved aquaporin 0 (AQP0), that is present predominantly in the lens mature fiber cells of the WT, functions as a water channel and a cell-to-cell adhesion (CTCA) protein in a knockin (KI) mouse model (AQP0ΔC/ΔC) that does not express intact A...

journal_title：Biochemical and biophysical research communications

authors： Kumari SS,Varadaraj K

更新日期：2019-04-09 00:00:00

abstract：:This study reports the X-ray crystallographic structure of the glycyl-tRNA synthetase (GlyRS) of Nanoarchaeum equitans - a hyperthermophilic archaeal species. This is the first archaeal GlyRS crystal structure elucidated. The GlyRS comprises an N-terminal catalytic domain and a C-terminal anticodon-binding domain with...

journal_title：Biochemical and biophysical research communications

authors： Fujisawa A,Toki R,Miyake H,Shoji T,Doi H,Hayashi H,Hanabusa R,Mutsuro-Aoki H,Umehara T,Ando T,Noguchi H,Voet A,Park SY,Tamura K

更新日期：2019-04-02 00:00:00

abstract：:Inactivated vaccines are widely used for prevention of viral disease. Both humoral and cellular immune responses have been shown to play important roles in the control and clearance of virus infections. CpG motif containing oligodeoxynucleotides (ODN) have recently gained considerable interest and been used as vaccine...

journal_title：Biochemical and biophysical research communications

authors： Liang H,Xiao X,Zhang X,Hu Q,Yang Y,Cen S,Deng X,Sheng W

更新日期：2019-04-02 00:00:00

abstract：:HMG-CoA reductase inhibitor statins are used to treat patients with hypercholesterolemia. The pleiotropic effects of statins have been recently extended to the regulation of angiogenesis. However, the observations on the effects of statins on endothelial cells seem to be contradictory. In this work, we systematically ...

journal_title：Biochemical and biophysical research communications

authors： Hu K,Wan Q

更新日期：2019-04-02 00:00:00

abstract：:Vascular endothelial cell (VEC) apoptosis takes part in the development of various cardiovascular diseases. Heat shock protein 90 (HSP90) regulates apoptosis through various apoptosis associated client proteins. In previous study, we identified a novel HSP90 inhibitor HCP1 induced apoptosis in A549 human lung cancer c...

journal_title：Biochemical and biophysical research communications

authors： Wei Q,Zhang J,Su L,Zhao X,Zhao B,Miao J,Lin Z

更新日期：2019-03-26 00:00:00

abstract：:Chromatin spatial organization is essential for transcriptional modulation and stabilization. The pattern of DNA distal interplay form the multiple topological associating domains (TADs), and further assemble the functional compartmentalization with open and expression-active chromatin ("A" compartments) or closed and...

journal_title：Biochemical and biophysical research communications

authors： Gong W,Liu Y,Qu H,Liu A,Sun P,Wang X

更新日期：2019-03-19 00:00:00

abstract：:In a previous genome-wide association study on milk production traits in Chinese Holstein population, we revealed VPS28 gene was highly expressed in mammary gland tissue and a -58C > T mutation in 5'-UTR of it was significantly associated with milk fat content traits. In this study, we explored the effect of this -58C...

journal_title：Biochemical and biophysical research communications

authors： Liu L,Zhang Q

更新日期：2019-03-19 00:00:00

abstract：:Dysregulation and aggregation of the peptide hormone IAPP (islet amyloid polypeptide, a.k.a. amylin) into soluble oligomers that appear to be cell-toxic is a known aspect of diabetes mellitus (DM) Type 2 pathology. IAPP aggregation is influenced by several factors including interactions with metal ions such as Cu(II)....

journal_title：Biochemical and biophysical research communications

authors： Dong X,Svantesson T,Sholts SB,Wallin C,Jarvet J,Gräslund A,Wärmländer SKTS

更新日期：2019-03-19 00:00:00

abstract：:The self-assembly of amyloid-beta (Aβ) proteins in aqueous extracellular environments is implicated in Alzheimer's disease. Among several alloforms of Aβ proteins differing in sequence length, the 42- and 40-residue forms (Aβ42 and Aβ40) are the most abundant ones in the human body. Although the only difference is the...

journal_title：Biochemical and biophysical research communications

authors： Lin Y,Im H,Diem LT,Ham S

更新日期：2019-03-12 00:00:00

abstract：:Human serum albumin (HSA) serves as a natural depot of amyloid β peptide (Aβ). Improvement of Aβ binding to HSA should impede Alzheimer's disease (AD). We developed a method for quantitation of the interaction between monomeric Aβ40/42 and HSA using surface plasmon resonance spectroscopy. The dissociation constant of ...

journal_title：Biochemical and biophysical research communications

authors： Litus EA,Kazakov AS,Sokolov AS,Nemashkalova EL,Galushko EI,Dzhus UF,Marchenkov VV,Galzitskaya OV,Permyakov EA,Permyakov SE

更新日期：2019-03-05 00:00:00

abstract：:Pathways formed of delocalized π-electron systems and polar groups of polypeptide chains bridged by hydrogen bonds are referred as π-H pathways. Suitable for electron transfer, these pathways in cytochrome c oxidase connect CuA, the source of electrons distributed in cytochrome c oxidase, with the metal centers, heme ...

journal_title：Biochemical and biophysical research communications

authors： Ramasarma T,Vaigundan D

更新日期：2019-03-05 00:00:00

abstract：:Activation of the receptor activator of nuclear factor-κB (RANK) by its ligand (RANKL) is involved in both solid and hematological malignancies, including multiple myeloma, acute myeloid leukemia and B-cell leukemia. Although RANKL expression has been described in normal T cells, a potential role in T-cell leukemia re...

journal_title：Biochemical and biophysical research communications

authors： Fernandes MT,Caroço LS,Pacheco-Leyva I,Dos Santos NR

更新日期：2019-03-05 00:00:00

abstract：:Locally applied radiation to the tumor is reported to stimulate systemic immune response. During radiotherapy to the abdominal cancer, spleen often receives certain dose, though as an important immune organ, little is known about the impact of splenic irradiation (SI) on systemic immune and local tumor control. Throug...

journal_title：Biochemical and biophysical research communications

authors： Chen HY,Xie HY,Liu XX,Li LF,Bai YR,Gao JX

更新日期：2019-02-26 00:00:00

abstract：:Unveiling the mechanism of the relapse of acute lymphoblastic leukemia (ALL) is the key to improve the prognosis of ALL and remains a huge challenge. Glycan-based interactions play a vital role in immune surveillance, cell-cell adhesion and cell-matrix interaction, contributing to treatment failure in tumor. However, ...

journal_title：Biochemical and biophysical research communications

authors： Yi L,Hu Q,Zhou J,Liu Z,Li H

更新日期：2019-02-26 00:00:00

abstract：:Adhesive ascidians have caused serious biofouling problems and huge economic losses in marine ecosystems. However, adhesion mechanisms, particularly on functional proteins involved in ascidian adhesion, remain largely unexplored. Here, we identified 26 representative stolon proteins from the highly invasive fouling as...

journal_title：Biochemical and biophysical research communications

authors： Li S,Huang X,Chen Y,Li X,Zhan A

更新日期：2019-02-26 00:00:00

abstract：:Worldwide, hepatocellular carcinoma (HCC) remains a top instigator of cancer mortality. Previous clinical studies have revealed that low serum cholesterol predicts a poor outcome in HCC patients, but the potential role of cholesterol in the progression of HCC remains controversial. In the present study,we tested the i...

journal_title：Biochemical and biophysical research communications

authors： Zhao Z,Zhong L,He K,Qiu C,Li Z,Zhao L,Gong J

更新日期：2019-02-19 00:00:00

abstract：:Angiotensin II (Ang II) modulates VSMCs phenotypic switch that play a critical role in the cardiovascular diseases. MicroRNA-27a (miR-27a) has been proven to be involved in regulating vascular remodeling; however, the functional role of miR-27a in VSMCs in response to Ang II stimulation need to be elucidated. Cell pro...

journal_title：Biochemical and biophysical research communications

authors： Xu MM,Deng HY,Li HH

更新日期：2019-02-19 00:00:00

abstract：:In this study, we found that lincRNA-TINCR was significantly upregulated in burn-injured skin tissues in vivo and heat-stimulated dermal fibroblasts in vitro, accompanied by an increase in TGF-β1 expression. TINCR overexpression promoted cell proliferation, colony formation, release of pro-inflammatory factors and exp...

journal_title：Biochemical and biophysical research communications

authors： Qin G,Song Y,Guo Y,Sun Y,Zeng W

更新日期：2019-02-19 00:00:00

abstract：:Runt-related transcription factor 2 (Runx2), also known as core binding factor 1 (Cbfa1), is a multifunctional transcription factor and an essential master gene controlling osteoblast differentiation. We previously demonstrated the in vivo functions of Runx2 in mesoderm-derived cells. However, no studies have been con...

journal_title：Biochemical and biophysical research communications

authors： Shirai Y,Kawabe K,Tosa I,Tsukamoto S,Yamada D,Takarada T

更新日期：2019-02-19 00:00:00

abstract：:Metallosphaera sedula is a thermoacidophilic autotrophic archaeon and known to utilize the 3-hydroxypropionate/4-hydroxybutyrate cycle (3-HP/4-HB cycle) as a carbon fixation pathway. The 3-HP/4-HB cycle in M. sedula is associated with central metabolism, and malate dehydrogenase (MDH) is an enzyme involved in the cent...

journal_title：Biochemical and biophysical research communications

authors： Lee D,Hong J,Kim KJ

更新日期：2019-02-12 00:00:00

abstract：:Atherosclerosis and cancer are the leading causes of mortality around the world that share common pathogenic pathways. The aim of this study is the investigation of the protein profile of atherosclerotic plaque in order to find similar biomarker between cancer and atherosclerosis. The small pieces of human coronary ar...

journal_title：Biochemical and biophysical research communications

authors： Fasehee H,Fakhraee M,Davoudi S,Vali H,Faghihi S

更新日期：2019-02-12 00:00:00

abstract：:Mitofusin1 (Mfn1) mediates outer mitochondrial membrane (OMM) fusion in Opisthokonts. The uncharacterized TM comprises to two helices (namely, the TM1 and TM2) connected by an intermembrane loop. Consistent with previous studies, our results from in silico analyses show that all mitofusins lack N terminal-MTS and the ...

journal_title：Biochemical and biophysical research communications

authors： Sinha S,Aradhyam GK

更新日期：2019-02-12 00:00:00

abstract：:T cell immunotherapies are promising options in leukemia, among which the CD19/CD3-bispecific T cell engager antibody blinatumomab (MT103) has shown high response rates at very low doses in patients with lymphoma. However, the high CD47 expression in human lymphoma cells has limited the curative effects of blinatumoma...

journal_title：Biochemical and biophysical research communications

authors： Xu L,Wang S,Li J,Li B

更新日期：2019-02-12 00:00:00

abstract：:Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra. Prevailing evidence suggests that abnormal autophagy and mitochondrial dysfunction participate in the process of PD. However, many damages of neuronal functions are regulated b...

journal_title：Biochemical and biophysical research communications

authors： Zhao M,Chen J,Mao K,She H,Ren Y,Gui C,Wu X,Zou F,Li W

更新日期：2019-02-05 00:00:00

abstract：:BST2 is an antiviral factor that inhibits the release of enveloped virus at the plasma membrane via an unusual topology in which its N-terminal is in the cytosol while its C-terminal is anchored by glycophosphatidylinositol (GPI). BST2-deficient cells showed substantially higher release of virions than wild type cells...

journal_title：Biochemical and biophysical research communications

authors： Yi E,Oh J,Kang HR,Song MJ,Park SH

更新日期：2019-02-05 00:00:00

abstract：BACKGROUND:Platelet microparticles (PMPs) are closely associated with diabetic macrovascular complications. This study aimed to explore the underlying mechanisms of high glucose-induced PMPs generation. METHODS:Washed platelets, obtained from the plasma of healthy male Sprague-Dawley rats, were incubated with high glu...

journal_title：Biochemical and biophysical research communications

authors： Wang GH,Ma KL,Zhang Y,Hu ZB,Liu L,Lu J,Chen PP,Lu CC,Ruan XZ,Liu BC

更新日期：2019-02-05 00:00:00

abstract：:PICOT is a ubiquitous protein that has no functional redundant ortholog and is critical for mouse embryonic development. It is involved in the regulation of signal transduction in T lymphocytes and cardiac muscle, and in cellular iron metabolism and biogenesis of Fe/S proteins. However, very little is known about the ...

journal_title：Biochemical and biophysical research communications

authors： Pandya P,Pasvolsky R,Babichev Y,Braiman A,Witte S,Altman A,Isakov N

更新日期：2019-02-05 00:00:00

abstract：:The mitochondrial ATP synthase of Polytomella exhibits a peripheral stalk and a dimerization domain built by the Asa subunits, unique to chlorophycean algae. The topology of these subunits has been extensively studied. Here we explored the interactions of subunit Asa3 using Far Western blotting and subcomplex reconsti...

journal_title：Biochemical and biophysical research communications

authors： Colina-Tenorio L,Miranda-Astudillo H,Dautant A,Vázquez-Acevedo M,Giraud MF,González-Halphen D

更新日期：2019-02-05 00:00:00

abstract：:Histone acetyltransferase MOF is involved in active transcription regulation through histone H4K16 acetylation. MOF is downexpressed in a number of human tumors, but biological function of MOF in endometrial cancer has not been fully defined. The estrogen receptor α (ERα) is a transcription factor that regulates estro...

journal_title：Biochemical and biophysical research communications

authors： Wu Y,Zeng K,Wang C,Wang S,Sun H,Liu W,Wang X,Niu J,Cong SY,Zhou X,Zhao Y

更新日期：2019-02-05 00:00:00

abstract：:Mesoporous silica nanoparticles (MSNPs) of a small diameter were loaded with the anticancer drug temozolomide (TMZ), coated with polydopamine (PDA), and conjugated with Asn-Gly-Arg (NGR) for use in the treatment of glioma. The accumulation of NGR-MSNPs in C6 cells was shown to be higher than that of unmodified MSNPs. ...

journal_title：Biochemical and biophysical research communications

authors： Zhang P,Tang M,Huang Q,Zhao G,Huang N,Zhang X,Tan Y,Cheng Y

更新日期：2019-02-05 00:00:00

abstract：:Co-transcriptional RNA proofreading by RNA polymerase (RNAP) is essential for accurate mRNA synthesis and reactivation of stalled transcription complexes, which can otherwise compromise genome integrity. RNAP from the stress-resistant bacterium Deinococcus radiodurans exhibits high levels of RNA cleavage in comparison...

journal_title：Biochemical and biophysical research communications

authors： Esyunina D,Kulbachinskiy A

更新日期：2019-01-29 00:00:00

abstract：:MicroRNAs (miRNAs) play crucial roles in the pancreatic carcinogenesis and progression. In the present study, we found that miR-9-5p was significantly downregulated in pancreatic cancer tissues and cell lines. The expression levels of miR-9-5p were negatively correlated with tumor stage and vessel invasion. Log-rank t...

journal_title：Biochemical and biophysical research communications

authors： Wang J,Wang B,Ren H,Chen W

更新日期：2019-01-29 00:00:00